Síndrome de Ogilvie: manejo actual a propósito de un caso

Objetivo: Dar a conocer las últimas recomendaciones para la sospecha, el diagnóstico y el tratamiento médico y quirúrgico del síndrome de Ogilvie. Material y método: Estudio descriptivo, retrospectivo, observacional; en formato de caso clínico y revisión de la literatura actual, a través de PubMed, Scielo y otros motores de búsqueda de artículos científicos. Discusión y Conclusiones: La seudoobstrucción colónica aguda o síndrome de Ogilvie consiste en un íleo adinámico severo y dilatación masiva de asas del colon en ausencia de obstrucción mecánica. Se presenta, principalmente, en pacientes postquirúrgicos o severamente enfermos. Tienen riesgo de perforación aproximado del 3% y una mortalidad del 50%, la mayoría de los pacientes responden al manejo médico conservador. La descompresión colonoscópica puede ser necesaria en pacientes que no responden al tratamiento médico de soporte y a la descompresión farmacológica con neostigmina. Distintos grados de isquemia y/o perforación colónica obligan la reso-lución quirúrgica urgente en algunos casos, lo que define la morbimortalidad. Es importante la sospecha clínica de este síndrome para evitar complicaciones posiblemente fatales.

Objective: To present the latest recommendations for the suspicion, diagnosis and medical and surgical treatment of Ogilvie syndrome. Materials and methods: Descriptive, retrospective, observational study; in clinical case format and review of the current literature, through PubMed, Scielo and other search engines for scientific articles Discussion and Conclusions: Acute colonic pseudo-obstruction or Ogilvie syndrome consists of a severe adynamic ileus and massive dilatation of the colonic loops in the absence of mechanical obstruction. It occurs in post-surgical or severely ill patients. They have a risk of perforation of approximately 3% and a mortality of 50%, most patients respond to conservative medical management. Colonoscopic decompression may be necessary in patients who do not respond to supportive medical treatment and drug decompression with neostigmine. Different degrees of colonic ischemia and / or perforation require urgent surgical resolution in some cases, which defines morbidity and mortality. Clinical suspicion of this syndrome is important to avoid possibly fatal complications.

Ogilvie’s Syndrome - A Complication of Severe COVID-19 Infection

@#A higher rate of gastrointestinal complications has been shown in COVID-19 patients admitted to the intensive care unit than their counterparts without COVID-19. Ogilvie’s syndrome or acute colonic pseudo-obstruction is described as colonic distension without mechanical obstruction, usually caused by infections, opioid use, renal dysfunction, and electrolyte imbalance. We report a patient with Ogilvie’s syndrome probably secondary to COVID-19. The patient was a 51-year-old man diagnosed as category 5 COVID-19, requiring intensive care treatment and mechanical ventilation. He developed transverse colonic perforation following large bowel dilatation, for which laparotomy and colectomy were done. Unfortunately, he succumbed to death due to intrabdominal sepsis with multiorgan failure. Possible pathogenesis of ileus in severe COVID-19 infection includes viral-induced autonomic nervous system dysfunction, viral-induced gut inflammation mediated by ACE-2 receptors located on the enterocytes, and ischaemic endothelialitis.

Ogilvie’s Syndrome – A Post-Operative Emergency in a Case of Carcinoma Rectum

Acute colonic pseudo obstruction or Ogilvie’s syndrome is a rare entity that is characterized by acute dilatation of the colon without any mechanical obstruction. It is usually associated with medical disease or surgery and rarely occurs spontaneously. If not diagnosed early, Ogilvie’s syndrome may cause bowel ischemia and perforation. Its early diagnosis and prompt treatment are the keystones to avoid any subsequent fatal complications. We report a case of acute intestinal pseudo obstruction causing post-operative wound dehiscence in a patient who underwent colostomy reversal following a Hartman’s procedure for a rectal carcinoma. We also review the clinical characteristics, diagnostic methods, and management of Ogilvie’s syndrome with reference to literature.

Ogilvie's Syndrome after Lumbar Spinal Surgery / 대한척추외과학회지

STUDY DESIGN: Case report. OBJECTIVES: We report a case of Ogilvie's syndrome following posterior decompression surgery in a spinal stenosis patient who presented with acute abdominal distension, nausea, and vomiting. SUMMARY OF LITERATURE REVIEW: Ogilvie's syndrome is a rare and potentially fatal disease that can easily be mistaken for postoperative ileus, and is also known as acute colonic pseudo-obstruction. Early recognition and diagnosis enable treatment prior to bowel perforation and requisite abdominal surgery. MATERIALS AND METHODS: An 82-year-old woman presented with 6 months of worsening back pain with walking intolerance due to weakness in both legs. She had hypertension, asthma, and Cushing syndrome without bowel or bladder symptoms. Further workup demonstrated the presence of central spinal stenosis on magnetic resonance imaging. The patient underwent an L2-3 laminectomy and posterior decompression. Surgery was uneventful. RESULTS: The patient presented with acute abdominal distension, nausea, and vomiting on postoperative day 1. The patient was initially diagnosed with adynamic ileus and treated conservatively with bowel rest, reduction in narcotic dosage, and a regimen of stool softeners, laxatives, and enemas. Despite this treatment, her clinical course failed to improve, and she demonstrated significant colonic distension radiographically. Intravenous neostigmine was administered as a bolus with a rapid and dramatic response. CONCLUSION: Ogilvie's syndrome should be included in the differential diagnosis of postoperative ileus in patients developing prolonged unexplained abdominal distension and pain after lumbar spinal surgery. Early diagnosis and initiation of conservative management can prevent major morbidity and mortality due to bowel ischemia and perforation.

Cecostomía endoscópica percutánea, una terapia eficaz en el síndrome de Ogilvie: relato de caso y revisión bibliográfica / Percutaneous endoscopic cecostomy, effective therapy for the treatment of Ogilvie syndrome: case and literature review

Ogilvie syndrome, or Acute Colonic Pseudo-Obstruction (ACPO) is characterized by colonic distension in the absence of mechanical obstruction. In general, it evolves favorably following a conservative treatment, and surgical procedures are not necessary6. We describe a case of ACPO with evolution of two days, in a 79-year old male patient, with asthma, type 2 diabetes mellitus, systemic arterial hypertension and policystic kidneys. After failure of conservative treatment based on support measures and neostigmine, percutaneous endoscopic support cecostomy, using a gastrostomy tube. The technique and its early execution were chosen considering that it was easy to be implemented, low cost and need for immediate colonic decompression due to high risk of ischemia and perforation of the colon, associated to a rapid clinical deterioration of the patient

El síndrome de Ogilvie o Pseudoobstrucción colónica aguda (ACPO) se caracteriza por la distensión del colon en ausencia de obstrucción mecánica. En general, el tratamiento conservador es favorable, no siendo necesaria una intervención quirúrgica. Describimos el caso de una ACPO con dos días de evolución, en paciente masculino de 79 años, asmático, portador de diabetes mellitus tipo 2, hipertensión arterial sistémica y riñones poliquísticos. Después del fracaso del tratamiento conservador con medidas de soporte y neostigmina, se optó por la realización de cecostomía endoscópica percutánea de protección, utilizando una sonda de gastrostomía. La elección de la técnica y su realización precoz se dio teniendo en vista su facilidad de ejecución, su bajo costo y la necesidad de descompresión colónica inmediata por el elevado riesgo de isquemia y perforación del colon, asociado al rápido empeoramiento clínico del paciente.

Seudoobstrucción colónica aguda o síndrome de Ogilvie en una anciana / Acute colonic pseudo-obstruction or Ogilvie syndrome in an old woman

La seudoobstrucción colónica aguda o síndrome de Ogilvie es una afección en la cual hay apariencia clínica e imagenológica de obstrucción intestinal sin bloqueo mecánico. Se describe el caso clínico de una anciana de 65 años de edad, quien sufría esta condición clínica, por lo cual fue atendida en el Servicio de Cirugía del Hospital N´Gola Kimbanda, provincia Namibe en Angola e intervenida quirúrgicamente. La paciente evolucionó favorablemente y egresó sin dificultad

The acute colonic pseudo-obstruction or Ogilvie syndrome is a disorder in which there is a clinical and imagenologic appearance of intestinal obstruction without mechanic blockade. The case report of a 65 years old woman who suffered from this clinical condition is described, reason why she was assisted and surgically intervened in the Surgery Service of N´Gola Kimbanda Hospital, Namibe province in Angola. The patient had a favorable clinical course and she was discharged without difficulty

Síndrome de Ogilvie após parto cesárea: relato de caso / Ogilvie's Syndrome after caesarean section: case report

Introdução: Descrita por Heneage Ogilvie em 1948, a síndrome que leva seu nome é caracterizada por uma dilatação do cólon simulando uma obstrução mecânica, possivelmente por conta de uma supressão parassimpática, ou estímulo excessivo parassimpático, resultando em uma atonia do cólon. O tratamento pode ser conservador, cirúrgico ou por descompressão colonoscópica. Relato: K.R.S.R, 41 anos, mulher, recém operada (cesariana), foi admitida relatando dor, distensão abdominal, constipação, ausência de flatos e febre. Disse já ter procurado serviço médico com queixas de constipação intestinal e apresentava-se hipotensa, taquicárdica, SpO2 94% e desidratada. O abdômen encontrava-se globoso, distendido, tenso, doloroso difusamente à palpação profunda, Blumberg +, timpânico à percussão, 18.600 leucócitos, 7% de bastonetes, Hb: 15,8 Ht: 46% e plaquetas: 349.000/mm³. Foi internada e submetida a USG abdominal, rotina radiológica de abdômen agudo e TC abdominal. Submetida à laparotomia exploradora, constatando dilatação desde o cólon ascendente até o cólon sigmóide e uma perfuração do ceco com cerca de 1cm. Realizou-se a aspiração da cavidade, rafia da lesão cecal e drenagem utilizando-se dreno túbulo laminar. Com boa evolução, teve alta no 5° dia pós-operatório, retirando o dreno posteriormente. 20 dias após o procedimento, retornou relatando dor abdominal, sendo submetida à USG de abdome que revelou coleção na goteira parietocólica direita. Esta foi drenada através de videolaparoscopia e, após boa evolução, a paciente recebeu alta no 2° dia pós-operatório. Conclusão: São necessários mais estudos para aprofundar o conhecimento sobre a síndrome.

Introduction: Described by Heneage Ogilvie in 1948, the syndrome that bears his name is characterized by a dilation of the colon simulating a mechanical obstruction, possibly due to a parasympathetic suppression or excessive parasympathetic stimulation, resulting in an atony of the colon. The treatment may be conservative, surgical or by colonoscopic decompression. Report: K.R.S.R, 41 years old, female, newly operated (caesarean section), was admitted reporting pain, bloating, constipation, absence of flatus and fever. Said she had sought medical service with constipation complaints and the patient was hypotensive, tachycardic, SpO2 94% and dehydrated. The abdomen was globose, distended, tense, painful diffusely to deep palpation, Blumberg +, tympanic to percussion, 18,600 leukocytes, 7% rods, Hb: 15.8 Ht: 46% and platelets: 349,000 / mm³. She was hospitalized and underwent to an abdominal ultrasonography, radiological routine, acute abdomen and abdominal CT. Submitted to laparotomy, finding dilation from the ascending colon to the sigmoid colon and cecal perforation of about 1cm. It carried out the suction cavity, suture the cecal lesion and drainage using laminar drain tubule. With good performance, she was discharged on the 5th postoperative day, removing the drain later that day. 20 days after the procedure, she returned reporting abdominal pain and was submitted to an abdomen USG revealed that the collection in the right parieto-colic drip. This was drained by laparoscopy and, after good performance, the patient was discharged on the 2nd postoperative day. Conclusion: Further studies are needed to increase knowledge about the syndrome.

Acute Colonic Pseudo-Obstruction (Ogilvie's syndrome) as a Complication of Herpes Zoster / 대한내과학회지

Acute colonic pseudo-obstruction (Ogilvie's syndrome) is a very rare complication of herpes zoster. A 62-year-old female visited our hospital due to abdominal pain. Skin lesions of herpes zoster had developed after the patient experienced symptoms of colonic obstruction. The symptoms of colonic obstruction resulted in more suffering for the patient than did those of herpes zoster. In cases reported previously in Korea, these symptoms were improved by endoscopic colonic decompression. However, the symptoms of this patient were improved by conservative treatment only, which included fasting and intravenous fluid replacement. Furthermore, this case differs from previous cases in terms of the difficulty of diagnosis due to the delayed appearance of the skin lesions. We present herein the first case in Korea of Ogilvie's syndrome as a complication of herpes zoster, which was improved by conservative treatment. Clinicians should be aware of the various unusual complications of herpes zoster.

Acute colonic pseudo-obstruction following allogeneic stem cell transplantation successfully treated by neostigmine

Acute colonic pseudo-obstruction (ACPO), also known as Ogilvie's syndrome, is a rare clinical syndrome of massive large bowel dilatation without mechanical obstruction, which may cause significant morbidity and mortality. Treatment focuses on decompressing a severely dilated colon. The proposed theory that this severe ileus results from an imbalance in the autonomous regulation of colonic movement supports the rationale for using neostigmine, a reversible acetylcholinesterase inhibitor, in patients who failed conservative care. Although gastrointestinal complications are frequent following allogeneic stem cell transplantation (SCT), the incidence of ACPO in a transplant setting is unknown and, if not vigilant, this adynamic ileus can be underestimated. We describe the case of a patient with myelodysplastic syndrome undergoing non-myeloablative allogeneic SCT from a partially human leukocyte antigen-mismatched sibling donor, and whose clinical course was complicated by ACPO in the early post-engraftment period. The ileus was not associated with gut graft-versus-host disease or infectious colitis. After 3 days of conservative care, intravenous neostigmine (2 mg/day) was administered for 3 consecutive days. Symptoms and radiologic findings began to improve 72 hours after the initial injection of neostigmine, and complete response without any associated complications was achieved within a week. Thus, neostigmine can be a safe medical therapy with successful outcome for patients who develop ACPO following allogeneic SCT.

Torsion of appendices epiploicae masquerading as ogilve’s syndrome.

Torsion of appendices ep loicae is an uncommon differential diagnosis of a patient presenting with acute abdominal pain and its presentation as a Ogilvie’s syndrome or colonic ileus is even rare.The diagnosis requires a keen suspicion on the part of the attending surgeon. Preoperative computrized tomography ( CT) may help in the diagnosis but the final diagnosis is established only on the operating table . Adding this pathology to the existing list of the causes of colonic ileus /Ogilvies syndrome may give us a good insight into the understanding of the condition&improvise our management. This is a case report of 60 year old lady who was referred to us with nonspecific abdominal pain , distention of abdomen and vomiting from orthopaedics department , where she was being planned for surgery for intertrochanteric fracture femur. All our investigations were equivocal and suggested a Ogilvie’s syndrome like picture .Atrial of neostigmine therapy was also given after excluding physical obstruction and the patient did not respond and the patient was operated upon and intraoperative finding of torsed epiploic appendage was found as the cause of her symptoms. The patient made a good post operative recovery following surgical excision of torsed epiploic appendages. This case should give us another dimension of thought in the management of such cases and help improvise our management.

A Rare Case of Ogilvie Syndrome Associated with Herpes Zoster

Acute colonic pseudo-obstruction (Ogilvie syndrome) associated with herpes zoster is extremely rare, and few cases have been reported. An 81-year-old woman diagnosed with herpes zoster was referred for accompanying colonic ileus. The diameter of the cecum was 7 cm and a computed tomographic scan showed no definite obstructive cause. Because the patient showed minimal improvement with conservative treatment, endoscopic colonic decompression was performed successfully. Previous studies revealed that the treatment of Ogilvie syndrome associated with herpes zoster does not differ from that of other conditions, and the role of the varicella-zoster virus in this syndrome is unclear. Here, we present the first case of Ogilvie syndrome associated with herpes zoster in Korea, which was improved by endoscopic colonic decompression.

Síndrome de Ogilvie poshisterectomía: reporte de un caso y revisión de la literatura(AU) / Ogilvie's syndrome post hysterectomy: a case report and literature review

Objetivo: presentar el estudio y el tratamiento que se le realizó a una mujer embarazada que presentó Síndrome de Ogilvie (SO) como complicación de una histerectomía obstétrica, así como describir la epidemiología,lafisiopatología,loshallazgosclínicos después de los procedimientos gineco-obstétricos y el tratamiento de esta patología mediante una revisión de la literatura. Presentación del caso: mujer de 28 años de edad con embarazo de 38 semanas de gestación quien después de parto vaginal eutócico sufrió atonía uterina. Debido a la falta de mejoría con el manejo médico, se le realizó una histerectomía abdominal subtotal, presentando picos febriles, intolerancia a la vía oral, taquicardia, distensión e hipertimpanismo abdominal con dolor a la palpación superficial y profunda en hemiabdomen derecho y peristaltismo disminuido durante el posoperatorio. La radiografía de abdomen evidenció un cuadro obstructivo con origen probable a nivel del intestino delgado, por lo que se le practicó una laparotomía exploratoria donde se le encontró peritonitis fecal y perforación colónica a nivel de la válvula ileocecal, sin evidencia de obstrucción mecánica. Discusión: el SO se caracteriza por la dilatación masiva y progresiva del colon en ausencia de una obstrucción mecánica. Se desarrolla principalmente en pacientes hospitalizadas con graves condiciones médico-quirúrgicas, pero también se presenta frecuentemente después de procedimientos gineco-obstétricos. Debido a que este síndrome se ha visto asociado con una alta morbimortalidad, es necesario que el gineco-obstetra lo tenga en cuenta como diagnóstico diferencial y esté atento a su presentación como complicación de cirugías obstétricas o ginecológicas.

Objective: presenting the workup and management of a pregnant woman who presented Ogilvie's syndrome as a complication of an obstetric hysterectomy and describing the epidemiology, physiopathology and clinical findings following gynecobstetric procedure and treatment of this pathology by means of a literature review. Case report: the case of a 28-year-old woman is presented; the patient presented uterine atony following normal vaginal delivery after 38 weeks' pregnancy. A subtotal abdominal hysterectomy was made due to lack of improvement with medical management. The patient presented fever, intolerance to oral route, tachycardia, distended and hypertympanic abdomen, pain in response to surface and deep palpation of the right hemi-abdomen and decreased peristalsis during postoperative period. The abdominal radiograph revealed obstruction of the small intestine; exploratory laparotomy was thus carried out, showing foetal peritonitis and perforation of the colon at the ileocecal valve without evidence of mechanical obstruction. Discussion: Ogilvie's syndrome is characterised by massive and progressive dilatation of the colon in the absence of small bowel obstruction. The syndrome mainly develops in hospitalised patients suffering from severe medical conditions; nonetheless, it also occurs after gynecobstetric procedures. Because this syndrome is associated with high rates of morbidity andmortality,thegynecobstetricianmustrecognise this syndrome as being a possible complication of gynecobstetric procedure.

Síndrome de Ogilvie (pseudo-obstrução intestinal aguda) - Relato de caso / Ogilvie's Syndrome (Acute pseudo-intestinal obstruction) - A case report

RACIONAL: A síndrome de Ogilvie é condição clínica com sinais, sintomas e aparência radiológica de dilatação acentuada do cólon sem causa mecânica e pode complicar com rompimento da parede do cólon e sepse abdominal. O tratamento na maioria das vezes é cirúrgico. RELATO DO CASO: Paciente feminina, 49 anos, internada com queixa de dor abdominal e diarréia e apresentando-se confusa, desidratada, taquicárdica, dispnéica, temperatura de 38ºC, abdômen distendido, ausência de ruídos hidro-aéreos e toque retal com fezes pastosas. Estudo radiográfico mostrou padrão de pseudo-obstrução intestinal. A paciente evoluiu com parada de eliminação de gases e fezes e sinais de abdômen agudo infeccioso. Foi submetida à laparotomia com achado de ceco e transverso bastante dilatados e sem sinal de obstrução mecânica. Realizada colectomia subtotal com fechamento do coto distal e ileostomia terminal. CONCLUSÃO: Pensar nessa possibilidade diagnóstica e agir mais rapidamente é a única possibilidade de diminuir a morbimortalidade desses pacientes.

BACKGROUND: The Ogilvie's Syndrome is a clinical condition with signals, symptoms and radiological appearance of large bowel swell without mechanical cause. This obstruction can complicate with disruption of the bowel and consequent evolution of abdominal sepse. The treatment is typically surgical. AIM: The aim of this work is report a case of Ogilvie's Syndrome. CASE REPORT: Feminine patient, 49 years-old, interned with a history of abdominal pain and diarrhea and presenting dehydratation, tachycardia , dyspnea, mental confusion, 38ºC of temperature, distended abdomen, absence of hydro-aerial noises and rectal touch with pasty excrements. The x-ray showed a standard of pseudo-intestinal obstruction. The patient evolved with stop of elimination of farts and excrements and signals of infectious acute abdomen. The laparotomy showed cecum and transverse very swelled without signal of mechanical obstruction. The treatment was a subtotal colectomy with closing of the rectal stump and terminal ileostomy. CONCLUSION: This is rare syndrome and cases like this must be described for a faster diagnostic and adequate treatment, reducing the morbimortality of these patients.

Eosinophilic Peritonitis Followed by Acute Colonic Pseudo-obstruction (Ogilvie's syndrome) in an ESRD Patient on CAPD / 대한신장학회잡지

Acute colonic pseudo-obstruction (Ogilvie's syndrome) is characterized by massive dilatation of the colon with no sign of mechanical obstruction. We report a case of eosinophilic peritonitis with severe abdominal pain followed by acute colonic pseudo- obstruction in an ESRD patient on CAPD. The intravenous administration of neostigmine, an acetylcholinesterase inhibitor, resulted in safe and effective colonic decompression in our patient. In case patients with acute colonic pseudo-obstruction do not respond to conservative therapy, treatment with neostigmine can be considered even for patients on dialysis.

Treatment of Acute Colonic Pseudo-obstruction (Ogilvie's Syndrome) with Intravenous Neostigmine

Acute colonic pseudo-obstruction is a functional disorder that closely mimics a mechanical large-bowel obstruction. Two such patients were treated by pharmacological manipulation of the parasympathetic innervation to the colon with intravenous neostigmine infusion. The two responded to treatment with passage with flatus and stool within several minutes with complete resolution of the symptoms, although the first patient required two additional infusions and the second patient required one additional infusion for subsequent recurrence. Dizziness occurred in one patient, and no other serious side effects were apparent. This pharmacological approach to the management of acute colonic pseudo-obstruction is suggested as an alternative to the other treatment options of colonoscopic decompression or surgery when conservative management has failed.

A Case of Colonic Pseudo-obstruction Two case reports

Pseudo-obstruction of the colon, first described by Ogilvie1 in 1948 and usually referred to as Ogilvie's syndrome, is a specific variety of adynamic ileus. It is characterized by massive colonic dilatation with a clinical and radiologic findings very similar to mechanical large intestinal obstruction, except that there is no organic obstruction. The cecum is usually the site of greatest dilatation, though the whole large bowel may be involved, from the terminal ileum up to the rectosigmoid junction. The dilatation is rapidly progressive and, if untreated, may even cause cecal necrosis and perforation, with highly increased mortality rate. The syndrome has been associated with various metabolic and organic dysfunctions, and has been observed following gynecologic as well as simple surgical procedures; yet its occurrence has been rather uncommon. The followings are two case reports with this syndrome.

OGILVIE`S SYNDROME AS A COMPLICATION AFTER THE BREAST RECONSTRUCTION WITH A TRAM FLAP

Acute colonic pseudoobstruction was first reported in 1948 by Sir H. Ogilvie. It is characterized by an acute, abrupt right-sided colonic distention in the absence of physical reasons for obstruction. If untreated, it may progress to cecal perforation, peritonitis, and death. Although primary cases have been reported, 87 percent of cases were secondary results of medical or surgical conditions. The most common medical conditions were infections, cardiac disease, and neurologic problems. In surgical conditions, cesarean section has been reported as the most common cause of Ogilvie's syndrome. In 1995, the first case of Ogilvie's syndrome complicated after a cosmetic surgical procedure(abdominoplasty) was reported by Bradley et al. We report a case of Ogilvie's syndrome complicated after breast reconstruction with TRAM flap that developed in the postoperative third day in 35-year old woman. The complications are primarily related to decreased flap perfusion. No reference of intestinal pseudoobstruction was found in the literature conducted in regard to complications of TRAM flap breast reconstruction.